A multicomponent approach to the synthesis of N-sulfonyl β(2,3)-amino esters.
نویسندگان
چکیده
The multicomponent synthesis of α,β-disubstituted N-sulfonyl β-amino esters is described. It involves a zinc-mediated, cobalt-catalyzed three-component reaction between sulfonylimines, acrylates and organic bromides. A possible mechanism is proposed, emphasizing the intermediate formation of an organocobalt as the initiator of a Mannich-like process.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 21 شماره
صفحات -
تاریخ انتشار 2014